What is the USMLE? COMLEX? All United States medical students are required to pass a three-step examination for medical licensure. Allopathic (MD) students are required to take the United States Medical Licensing Examination (USMLE) whereas Osteopathic (DO) students are required to take the Comprehensive Osteopathic Medical Licensing Examination (COMLEX). The purpose of these exams is … More Should I take USMLE Step 1?